AMP for email is a terrible idea | TechCrunch

Source: AMP for email is a terrible idea | TechCrunch, by Devin Coldewey

What is the vast majority of “live” content on the web, stuff that needs to call home and update itself? Not articles like this one, or videos or songs — those are just resources you request. Not chats or emails. Cloud-based productivity tools like shared documents, sure, granted. But the rest — and we’re talking like 99.9 percent here — is ads.

Ads and trackers that adapt themselves to the content around them, the data they know about the viewer, and the latest pricing or promotions. That’s how Google wants to “modernize” your inbox.

Does “engaging, interactive, and actionable email experiences” ring a little different now?

A Better Way to Look at Most Every Political Issue – The Atlantic

Source: A Better Way to Look at Most Every Political Issue – The Atlantic, by Conor Friedersdorf

We sometimes think of political issues in binary terms. Is someone pro-life or pro-choice? But most individuals hold views that are more complicated than a binary can capture.

An alternative is to describe a given position on a spectrum. On abortion, an outright ban sits at one extreme; at the other is the elimination of all restrictions on the procedure. In between are a staggering array of coherently distinguishable positions.

There’s a different set of frames, though, that are as relevant as binaries and spectrums, though they are less familiar and less discussed: equilibriums and limits.

Most political stances can be understood in terms of an equilibrium. For instance, some people might believe that access to abortion in a conservative state is too restricted under the status quo, and favor relaxing the rules regulating abortion clinics. That is, they might favor shifting the equilibrium in a “pro-choice” direction.

But ask those same voters, “Should there be any limits on legal abortion?” and they might declare that the procedure should be banned in the last trimester of pregnancy unless the mother’s health is threatened. Insofar as the abortion debate is framed around the equilibrium, they will align with the pro-choice movement; but insofar as it is framed around limits, they will align with the pro-life movement.

On abortion and scores of other political issues, there are people who tend to focus on equilibriums, other people who tend to focus on limits, and still others who vary in their focus. A single question put to the public cannot reveal the majority position of the polity on such issues, because there are at least two different majority coalitions: One forms around the position that a majority holds on the best equilibrium; the other forms around the position a majority holds on the appropriate limit.

Contempt for Court – The Atlantic

Source: Contempt for Court – The Atlantic, by Garrett Epps

Republican lawmakers are increasingly showing disdain for decisions made the judicial branch—and by extension the rule of law.

In short, Pennsylvania is in the middle of a state constitutional crisis, and one side of the dispute is willing to threaten the independence of the state’s courts for the chance at six extra House seats.

This partisan assault on the courts is only the tip of a nationwide spear—Republican efforts to purge and remodel state courts to make sure they follow the party’s line. … The independent judiciary is all very well, until it gets in the way of one-party rule.

Insider trading has been rife on Wall Street, academics conclude – In the know | The Economist

Source: Insider trading has been rife on Wall Street, academics conclude – In the know | The Economist

One study suggests insiders profited even from the global financial crisis; another that the whole share-trading system is rigged.

The papers make imaginative use of pattern analysis from data to find that insider trading is probably pervasive. The approach reflects a new way of analysing conduct in the financial markets. It also raises questions about how to treat behaviour if it is systemic rather than limited to the occasional rogue trader.

Why does drug resistance readily evolve but vaccine resistance does not? | The Royal Society

Source: Why does drug resistance readily evolve but vaccine resistance does not? | Proceedings of the Royal Society of London B: Biological Sciences, by David A. Kennedy, Andrew F. Read

Time to first detection of human pathogens resistant to vaccines and antimicrobial drugs. Viral vaccines are labelled in purple, bacterial vaccines are labelled in green. Blue ‘x’s denote the first observations of resistance, with lines starting at product introduction (except for smallpox vaccination which began much earlier). Note that in all cases, substantial public health gains continued to accrue beyond the initial appearance of resistance.

Why is drug resistance common and vaccine resistance rare? Drugs and vaccines both impose substantial pressure on pathogen populations to evolve resistance and indeed, drug resistance typically emerges soon after the introduction of a drug. But vaccine resistance has only rarely emerged. Using well-established principles of population genetics and evolutionary ecology, we argue that two key differences between vaccines and drugs explain why vaccines have so far proved more robust against evolution than drugs. First, vaccines tend to work prophylactically while drugs tend to work therapeutically. Second, vaccines tend to induce immune responses against multiple targets on a pathogen while drugs tend to target very few. Consequently, pathogen populations generate less variation for vaccine resistance than they do for drug resistance, and selection has fewer opportunities to act on that variation. When vaccine resistance has evolved, these generalities have been violated. With careful forethought, it may be possible to identify vaccines at risk of failure even before they are introduced.